Whether it is a house or a daycare center, if a project is serving neuro-divergent (ND) clients—those who have autistic spectrum disorder—, lowering their sensory stress and the work stress of their caregivers would be the primary design objective. The first step would be to gather knowledge of the ND clients' sensory profiles, sensory worlds, and the logic of coping behaviors. This would be accomplished through meetings with the ND clients and their caregivers as well as on-site observations of the ND clients when possible.

Understanding ND Clients
While every ND person's sensory profile is unique, generally speaking, due to the neurological conditions they have hypersensitivities to sensory stimuli such as bright light, fluorescent light, certain colors, strong visual patterns, sound, touch, smell, and taste. Sensory overload can be experienced as extreme physical pain or discomfort in their nervous system. Hypersensitivities can occur not only in terms of intensity but also of duration, which means that for ND persons sensations can remain much longer - a number of hours, even days after the physical sensory stimuli has been removed.

ND persons' vision may lack depth, be distorted, and be so chaotic beyond intelligibility as perceived objects never settle down, continue to slither, change in shape and size, or even disappear especially when they try to concentrate on looking.
The majority of ND persons' visual hypersensitivity and distorted vision can be alleviated by wearing colored lenses ("Irlen Lenses") that filters out the wavelengths of light to which they are hypersensitive.

When designing the physical environment for ND persons, it is crucial to understand what stimuli they are hypersensitive to, what their sensory worlds are like, how sensory overload occurs, and the logic of their seemingly bizarre reactions & coping behaviors. Hypersensitivities can get worsen during puberty and may change over time.
On the other hand, generally many ND persons are hypo-sensitive to internal bodily feeling such as thirst, hunger, digestion, pain, heart rate, muscle tensions, and sensations in bowel, bladder, etc, which can lead to constipation and incontinence. Impaired sense of balance and body movement awareness are not uncommon, either. Since emotions are closely related one's bodily sensations, it is also harder for ND persons to recognize their own emotions, which affects their self-control skills. Poor interoceptive awareness combined with the chaotic external sensory world perception may hinder the development of sense of self, which can lead to low self-esteem.

Basic Design Recommendations
While design recommendations would vary from one project to another, below two seem to be commonly prioritized.
Bathroom & laundry room optimized for toilet assistance or training, incontinence cleanup, and bathing
Spaces ND persons use should be made tranquil & safe according to their sensory profiles, durable, and easy to clean.
By reducing physical environmental sensory stressors, architectural design can free ND clients from having to compensate for sensory overloads which in turn improves processing of overall senses including interoception.
Note
In this post the word ND refers to the neuro-developmental conditions known as autistic spectrum disorder with or without intellectual disability.
References
The sources YA learned about ND persons sensory issues from include the following books & websites.
Caldwell, P. (2006) Finding You Finding Me. London: Jessica Kingsley Publishers
On the topic of interoception related issues: https://autismawarenesscentre.com,
On the topic of visual sensitivity: www.integratedtreatmentservices.co.uk
Dr. Bogdashina's website: https://www.olgabogdashina.com